On the part of the cardiovascular system: heart rate, shortness of primobolan depot cycle breath, marked reduction in blood pressure, fainting, vasculitis, edema (swelling of the ankles and feet), “tides” of blood to the face, rarely – arrhythmias (bradycardia, ventricular tachycardia, atrial flutter) , chest pain, orthostatic hypotension, very rarely – the development or exacerbation primobolan side effects of congestive heart failure, arrythmia, migraine.On the part of the central nervous system: headache, dizziness, fatigue, drowsiness, mood changes, seizures; rare – loss of consciousness, hypoesthesia, nervousness, paresthesia, tremor, vertigo, fatigue, malaise, insomnia, depression, unusual dreams, very rarely – ataxia, apathy, agitation, amnesia.
From the digestive system: nausea, vomiting, epigastric pain, rarely – increased level of “liver” transaminases and jaundice (caused by cholestasis), pancreatitis, dry mouth, flatulence, gingival hyperplasia, constipation or diarrhea, rarely – gastritis ,, increased appetite. From the urogenital system: rare – pollakiuria, painful desires urination, nocturia, sexual dysfunction (including potency decrease), rarely – dysuria, polyuria. For the skin: very rarely – dermatoxerasia, alopecia, dermatitis, purpura, skin discoloration.Allergic reactions: itching, rash (including erythematous, maculopapular rash, urticaria), angioedema. From the musculoskeletal system: rarely – arthralgia, arthritis, myalgia long-term use, very rarely – myasthenia gravis. The other: seldom – gynecomastia, poliurikemiya, increase / reduction in weight body, thrombocytopenia, leukopenia, hyperglycemia, impaired vision, conjunctivitis, diplopia, eye pain, tinnitus, back pain, dyspnoea, epistaxis, increased sweating, thirst; very rarely – a cold clammy sweat, cough, rhinitis, parosmiya, taste disturbance, arushenie accommodation, xerophthalmia.
Overdose Symptoms: marked reduction of blood primobolan depot cycle pressure, tachycardia, excessive peripheral vasodilation, tachycardia. Treatment: gastric lavage, the appointment of activated carbon, the maintenance function of the cardiovascular system, the control parameters of the heart and lung function, elevated position limbs, control of blood volume and diuresis primobolan results. To restore vascular tone – use of vasopressors (in the absence of contraindications to their use); to eliminate the effects of calcium channel blockade – intravenous calcium gluconate. Hemodialysis is not effective.
Interactions with other drugs inhibitors of microsomal oxidation increase the concentration of amlodipine in plasma, increasing the risk of side effects, and inducers of microsomal liver enzymes – reduce. Antihypertensive effect of weakening non-steroidal anti-inflammatory drugs, especially indomethacin (sodium retention and synthesis of prostaglandins kidney blockade), Alpha adrenostimulyatorov , estrogens (sodium retention), sympathomimetic. Thiazide and “loop” diuretics, alpha, beta-blockers, veropamil, angiotensin-converting enzyme inhibitors and nitrates increase antianginal and antihypertensive effects. Amiodarone, quinidine, alpha 1-blockers, antipsychotic drugs (neuroleptics) and blockers “slow” calcium channels may increase the hypotensive effect. It has no impact on the pharmacokinetic parameters of digoxin and warfarin. Cimetidine did not affect the pharmacokinetics of amlodipine. When used together with lithium preparations primobolan results before and after, may increase manifestations of neurotoxicity (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus). calcium can reduce the effect of blockers “slow” calcium channels. procainamide, quinidine and other drugs causing prolongation of the interval , reinforce the negative inotropic effect and may increase the risk of significant lengthening interval. Pharmacokinetics of amlodipine does not change with concomitant administration with cimetidine. grapefruit juice may reduce amlodipine plasma concentration, but this decrease is so small that it does not significantly alter the effect of amlodipine.
Cautions During treatment Tenoksom necessary to monitor the primobolan depot cyclebody weight and sodium intake, the appointment of an appropriate diet. It is necessary to maintain dental hygiene and frequent visits to the dentist (to prevent soreness, bleeding and gingival overgrowth). Elderly patients can be prolonged half-life and clearance of the drug. The dosage regimen for the elderly is the same as for the patients in other age groups. By increasing the dose should be carefully monitored for elderly patients. Despite the lack of blockers “slow” calcium channels “cancellation” syndrome, before stopping treatment recommended a gradual reduction in dose. Effects on ability to drive a car and mechanisms There were no reports on the effect of Tenoksa on driving or operate machinery. However, some patients, especially at the beginning primobolan cycle of the treatment, there may be drowsiness and dizziness. If this happens, the patient must take special precautions when driving and operating machinery.