Fexofenadine slightly metabolized in liver and elsewhere, as evidenced by the fact that it is the only substance detectable in significant amounts in the urine and feces of humans and animals. in exchange taking the drug fexofenadine elimination curve primobolan depot for sale of the plasma decreases biekspotentsialno, and terminal half-life is 11-15 hours. Pharmacokinetics with a single and course intake fexofenadine (up to 120 mg twice a day orally) is linear. The dose of 240 mg twice a day gives a slightly more than proportional (8.8%) increase in the area under “concentration-time” curve, which indicates that the pharmacokinetics of fexofenadine is substantially linear over a dose range from 40 to 240 mg per day . According to most of the dose at the time of the data currently available in unchanged form excreted in the bile, and up to 10% of the drug – in the urine.
Indications of seasonal allergic rhinitis (to reduce the symptoms) – Tablets, 120 mg. Chronic idiopathic urticaria (to reduce the symptoms) – Tablets, 180 mg.
- Hypersensitivity to any component of the drug.
- Children’s age (12 years).Carefully:
- in patients with chronic renal and hepatic failure, as well as in elderly patients (lack of clinical experience with this category of patients);
- in patients with cardiovascular disease, including a history (antihistamines can cause palpitations and tachycardia, see “Side effects” section).Pregnancy and lactation Pregnancy There is insufficient data on the use of fexofenadine for pregnant primobolan depot for sale women. Limited animal studies have shown no evidence of the presence of adverse effects on pregnancy, prenatal development, childbirth and postnatal development. Fexofenadine should not be used during pregnancy. Lactation Data on the content of fexofenadine in breast milk when taking breast-feeding women are not available. However, when taking terfenadine seen its penetration in the breast milk of lactating women. Therefore, the use of fexofenadine during lactation period is not recommended.
Dosing and Administration The tablets are for oral use. The recommended dose of fexofenadine in seasonal allergic rhinitis for adults and children 12 years and older is 120 mg once a day before meals. The recommended dose of fexofenadine primobolan half life with chronic hives for adults and children 12 years and older is 180 mg once a day before meals. patients at risk Studies in special risk groups (elderly patients, patients with renal and hepatic impairment) have shown that they do not require a correction mode.
Side effects: In placebo-controlled clinical trials, the most frequently (≥1% – ≤10%) the observed undesirable effects were headache (7.3%), drowsiness (2.3%), dizziness (1.5%) and nausea 1 ,5%. When receiving fexofenadine frequency of the above adverse effects was similar to that of placebo. In placebo-controlled trials with a frequency of less than 1% (same for receiving fexofenadine and placebo) and post-marketing use of the drug are weakness, insomnia, nervousness and sleep disorders or abnormal dreams ( paroniriya) such as nightmares; tachycardia, palpitations; diarrhea. In rare cases (≥0,01% – ≤0,1%) were observed rash, urticaria, pruritus and other hypersensitivity reactions such as angioedema, difficulty in breathing, shortness of breath, flushing of the skin, systemic anaphylactic reactions.
Overdose Symptoms In case of overdose observed dizziness, drowsiness and dry mouth. Healthy volunteers received single doses of 800 mg and course doses up to 690 mg two times a day for 1 month or 240 mg two times a day for 1 year without any significant adverse effects compared with placebo. The primobolan depot for sale maximum tolerated dose has not been established for fexofenadine. Treatment In case of overdose is recommended to perform gastric lavage, administration of activated charcoal, if necessary, symptomatic and supportive therapy. Hemodialysis is ineffective.
Interaction with other medicinal products is increased 2-3 times a joint application fexofenadine with erythromycin or ketoconazole fexofenadine plasma concentration, but it is not associated with a significant prolongation of the interval. There were no significant differences in the incidence of adverse effects with these drugs in monotherapy and in combinations. Animal studies have shown that the above-mentioned increase in plasma concentrations of fexofenadine is probably due to improved absorption of fexofenadine and decrease its biliary excretion or secretion into the lumen of the gastrointestinal tract. The interaction between fexofenadine and omeprazole was observed. Do not interact with drugs metabolized in the liver. Reception aluminum or magnesium containing antacids 15 minutes before receiving fexofenadine bioavailability leads to decrease in the latter is apparently a result of binding in the gastrointestinal tract.
Specific guidance is recommended that the period of time between the reception of fexofenadine and antacids containing aluminum hydroxide or magnesium is at least 2 hours. For use in children aged 6 to 11 years are released tablets of 30 mg.
Effects on ability to drive and perform tasks requiring concentration When receiving the drug may perform activities primobolan depot for sale that require high concentration and speed of psychomotor reactions (except in patients who have non-standard reaction). Therefore it is recommended to pursue such activities to check the individual response to the reception of fexofenadine.