Following oral administration of amlodipine slowly absorbed from the gastrointestinal tract. The mean absolute bioavailability of 64%, the maximum concentration in serum is observed after 6-9 hours. The concentration of stable equilibrium is reached after 7 days of treatment. Food does not affect the absorption of amlodipine. The mean volume of distribution of 21 l / kg body weight, indicating that most of the drug is in the tissues and relatively smaller – in the blood. Most of the drug present in the blood (95%), bind to plasma proteins. Amlodipine undergoes slow but extensive metabolism (90%) in the liver into inactive metabolites, has the effect of “first pass” through the liver. Metabolites not possess significant pharmacological activity. After a single oral half-life (T 1/2 ) ranges from 31 to 48 hours when re-assigning the T 1/2 of about 45 hours. About 60% of an oral dose is excreted in the urine primarily as metabolites, 10% unchanged, and 20-25% in the feces and in breast milk. Amlodipine Total clearance is primobolan depot side effects In older patients (over 65 years) amlodipine slowed elimination (T 1/2 of 65 hr.) Compared young patients, but the difference has no clinical significance. Elongation T 1/2 in patients primobolan side effects with hepatic failure suggests that long-term administration with drug accumulation in the body is higher than (T 1/2 to 60 hours). Renal failure has no significant effect on the kinetics of amlodipine. The drug crosses the blood-brain barrier. When hemodialysis is not removed.
Indications Arterial hypertension (monotherapy or in combination with other antihypertensive agents) Stable and vasospastic angina (Prinzmetal angina)
- Hypersensitivity to amlodipine and other primobolan depot side effects dihydropyridine derivatives;
- severe hypotension,
- collapse, cardiogenic shock,
- pregnancy and lactation
- age of 18 years (effectiveness and safety have been established).
With caution: liver dysfunction, sick sinus syndrome (bradycardia, tachycardia), decompensated chronic heart failure primobolan dosage, mild or moderate hypotension, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and for 1 month after) , diabetes, lipid profile, old age.
Dosing and Administration Inside, the initial dose for the treatment of arterial giperteizii and angina is 5 mg once daily. The dose may be increased to a maximum of 10 mg once a day. When hypertension maintenance dose can be 2.5-5 mg per day. When angina and vasospastic angina – 5-10 mg per day, once. To prevent strokes -. 10 mg / Thin patients, patients with a short, elderly patients, patients with impaired liver function as a hypotensive agent, administered in an initial dose of 2.5 mg, as a means of antiangialnogo – 5 mg. Not required changing the dose with concomitant administration pronabolin side effects with thiazide diuretics, beta-blockers and angiotensin-converting enzyme primobolan depot side effects. not required dose modification in patients with renal insufficiency.